HHC – What is it?
In the ever-evolving landscape of the cannabis industry, a new star has emerged, captivating enthusiasts and researchers alike: HHC. Short for Hexahydrocannabinol, HHC represents the cutting edge of cannabinoid innovation, promising a unique experience for users and sparking curiosity among those delving into the realms of cannabis science.
But what exactly is HHC, and what makes it such a compelling force in today’s market?
Understanding HHC
Hexahydrocannabinol, commonly known as HHC, is a cannabinoid that has been a subject of scientific knowledge for quite some time but has only recently garnered attention within the cannabis community. This compound is closely related to THC, the well-known psychoactive component of cannabis, but differs slightly in its molecular structure. These minor differences can lead to distinct effects in the body, setting HHC apart from its more famous relative.
HHC is classified as a minor cannabinoid because it occurs naturally in cannabis in very small quantities, making natural extraction impractical and costly. However, advancements in cannabinoid conversion techniques have made it possible to produce HHC commercially. Similar to how delta 8 THC and delta 10 THC are synthesized, HHC is typically created from hemp-derived CBD in laboratory settings through specific chemical processes.
One of the significant advantages of HHC over delta 8 and delta 10 THC is its legal status. Despite having psychoactive properties, HHC is not labeled as THC, which helps it navigate through certain legal restrictions that apply to THC variants. This legal advantage has contributed to the recent surge in HHC’s popularity and availability in the global cannabis market.
HHC’s recent rise to prominence is partly due to its potential to offer unique effects compared to other cannabinoids. While THC is known for its strong psychoactive effects and CBD for its therapeutic benefits without the high, HHC provides an alternative that may combine some of the desirable properties of both. This has piqued the interest of hemp consumers and researchers alike, who are keen to explore the potential benefits and applications of this relatively obscure cannabinoid.
What Benefits Does HHC Bring?
Hexahydrocannabinol (HHC) is emerging as a cannabinoid of interest, despite the current lack of extensive research to fully substantiate its benefits. Like other cannabinoids, HHC interacts with the body’s endocannabinoid system (ECS), which plays a crucial role in regulating various physiological functions such as sleep, mood, appetite, memory, and reproductive health. The ECS includes receptors like CB1, predominantly located in the central nervous system, where HHC binds to exert its effects.
Relaxation and Stress Relief
Anecdotal reports suggest that HHC may provide significant relaxation and stress relief. Users have noted that HHC helps to calm the mind and alleviate stress, potentially making it a beneficial supplement for those seeking natural ways to manage everyday stressors.
Increasing Energy Levels
Some users claim that HHC boosts energy levels, making it a possible alternative for those looking for a natural stimulant. This property might make HHC appealing to individuals needing an extra push to get through their daily activities without the jittery effects associated with caffeine.
Support for Quality Sleep
HHC is believed to aid in improving sleep quality. Research from 2010 suggests that HHC can have long-lasting effects that support better sleep. Users have reported that it helps them fall asleep faster and stay asleep longer, which could be particularly beneficial for those struggling with insomnia or other sleep disorders.
Physical Comfort
There are indications that HHC may help with physical discomfort. Although the evidence is still emerging, users have reported relief from various types of physical pain. This aligns with the general effects of cannabinoids, which are known to interact with pain pathways in the body.
Anxiety Relief
Similar to CBD, HHC may help with anxiety. Users have noted a reduction in anxiety symptoms after consuming HHC, which could make it a useful tool for managing anxiety disorders.
Chronic Pain Management
Preliminary animal studies and user experiences suggest that HHC might be effective in managing chronic pain. A 2007 study by Japanese researchers highlighted HHC’s pain-blocking capabilities in mice, pointing towards its potential as a pain management solution.
Nausea and Vomiting Relief
HHC might also help in relieving nausea and vomiting, making it potentially beneficial for individuals undergoing treatments that cause these symptoms, such as chemotherapy.
Scientific Studies
Despite promising anecdotal reports and preliminary research, HHC has not been widely studied. A 2011 study did indicate that some synthetic analogs of HHC could strongly inhibit breast cancer cell-induced angiogenesis and tumor growth. These findings suggest that HHC might have anti-cancer properties, but further research is needed to confirm these effects and understand their implications fully.
Formation of HHC
HHC, or hexahydrocannabinol, was first synthesized in the 1940s by chemist Roger Adams. He achieved this by adding hydrogen to the THC molecule, a process known as hydrogenation. This method, detailed in a 1947 patent, involves modifying the structure of delta 9 THC by replacing a double bond with two hydrogen atoms.
This alteration increases the molecular weight of the compound and enhances its stability, making it more resistant to degradation caused by heat and UV light. According to Mark Scialdone, a chemist, and BR Brands Chief Science Officer, hydrogenation significantly improves HHC’s shelf life and resistance to thermo-oxidative breakdown.
Natural Formation
In nature, HHC is one of the many active substances produced as cannabis matures. It was only discovered in its natural form in 2020 by a team of scientists from Spain who analyzed the lipid extract from Cannabis sativa L.
Although the trichomes of the cannabis plant contain the highest concentration of cannabinoids, HHC is present only in trace amounts. The predominant cannabinoids in these trichomes are THC and CBD, making the extraction of natural HHC impractical and costly.
Chemical Synthesis
The synthetic form of HHC was discovered much earlier, in 1944, by Roger Adams. The process he used, hydrogenation, involves chemically converting delta 9 THC into HHC. This is done by adding hydrogen molecules to the THC compound, specifically replacing a carbon bond with two hydrogen atoms.
This process is analogous to the one used to transform sunflower oil into margarine, resulting in a more stable and long-lasting compound. The synthesized HHC is semi-synthetic, exhibiting characteristics similar to natural HHC found in the cannabis plant.
Advantages of Hydrogenation
Hydrogenation enhances the stability and shelf life of HHC. The resulting compound is more resistant to environmental factors such as sunlight and temperature changes, allowing for longer storage compared to THC products. This stability makes HHC a more viable option for commercial production and use in various products.
HHC’s Mechanism of Action
Binding to Cannabinoid Receptors
HHC acts as a partial agonist and antagonist at the CB1 and CB2 receptors. These receptors are located throughout the body, but CB1 receptors are primarily found in the central nervous system, while CB2 receptors are more common in peripheral tissues and immune cells. By binding to these receptors, HHC can influence various cellular responses, much like THC. However, HHC’s effects are generally weaker than those of delta-9-THC but more potent than delta-8-THC.
Partial Agonist and Antagonist Effects
As a partial agonist, HHC can activate cannabinoid receptors, leading to similar psychoactive and physiological effects as THC, albeit to a lesser degree. As an antagonist, it can also block certain receptor activities, modulating the overall effect. This dual action allows HHC to exhibit both stimulating and inhibitory effects on neuronal activity, impacting mood, perception, and energy levels.
Effects on the Nervous System
When ingested in dried or oil form, HHC enters the bloodstream and travels to the brain, where it binds to cannabinoid receptors affecting specific neurons. This interaction influences various aspects of brain function and behavior, including:
- Activity and Perception: HHC can alter sensory perception and cognitive processes, similar to THC. Users may experience changes in how they perceive time, space, and their environment.
- Mood: The compound can affect mood by interacting with receptors involved in regulating emotional responses. This can result in feelings of euphoria, relaxation, or altered emotional states.
- Energy Levels: HHC may modulate energy levels, providing either a stimulating or calming effect depending on the dosage and individual response.
- Other Aspects: HHC also impacts appetite, memory, and potentially pain perception, contributing to its therapeutic potential.
How Does HHC Compare to THC?
HHC is less potent than delta-9-THC, meaning it produces milder psychoactive effects, which can be beneficial for users seeking a more controlled and manageable experience. However, it is more potent than delta-8-THC, making it a middle-ground option for those looking for effects stronger than delta-8 but not as intense as delta-9.
How to Dose HHC?
Hexahydrocannabinol (HHC) is known for its intoxicating effects, which are somewhat similar to those produced by Delta 8 and Delta 9 THC, but generally about ¾ as potent as Delta 9 THC. This makes HHC an attractive option for those seeking a manageable and less intense psychoactive experience.
Despite its milder effects, caution is still necessary when dosing HHC, especially for new users.
Recommended Safe HHC Dosage
- HHC Gummies: One Gummy
- Advantages: Gummies provide a convenient, pre-measured dose, making them ideal for beginners.
- Dosage: Starting with one gummy allows users to accurately gauge their response to HHC. It’s a controlled way to experience the compound’s effects without the risk of overconsumption.
- Tip: Wait at least two hours after consuming a gummy before deciding to take more, as edibles take longer to produce their full effects.
- HHC Oil: One Dropperful
- Advantages: Tinctures offer precise control over dosing, allowing users to adjust their intake easily.
- Dosage: Begin with one dropperful of HHC oil. This provides a clear, consistent dose and helps users experience HHC’s effects gradually.
- Tip: Hold the oil under your tongue for about 30-60 seconds before swallowing to enhance absorption and onset.
- HHC Vape: Three Puffs
- Advantages: Vaping allows for quick onset and easy titration of the dose. Users can feel the effects almost immediately and can control their intake in real time.
- Dosage: Start with three puffs from a vape cartridge or disposable vape. This introductory amount is generally sufficient to feel the effects without being overwhelming.
- Tip: Wait a few minutes between puffs to assess the effects before taking more, ensuring a comfortable experience.
Tips for Safe and Effective HHC Use
- Start Low and Go Slow: This principle is crucial for anyone new to HHC. Begin with the recommended doses and gradually increase only if needed.
- Monitor Effects: Pay attention to how your body reacts to the initial dose. Everyone’s endocannabinoid system is different, so the effects can vary widely.
- Be Patient with Edibles: Since edibles take longer to kick in, avoid the temptation to take more too soon. This helps prevent uncomfortably strong effects later.
- Stay Hydrated: Drinking water can help mitigate some side effects like dry mouth and ensure a more comfortable experience.
- Consider Your Environment: Use HHC in a safe, comfortable setting, especially if it’s your first time. This helps you stay relaxed and enjoy the experience without unnecessary stress.
Frequently Asked Questions
Is HHC legal?
HHC is currently considered legal under federal law, thanks to the 2018 Farm Bill, which legalized hemp and its derivatives as long as they contain less than 0.3% delta 9 THC. Although HHC occurs naturally in cannabis, commercially available HHC is produced by hydrogenating hemp-derived cannabinoids, a process that results in a “semi-synthetic” compound.
Does HHC produce side effects?
There is limited research on the side effects of HHC. Anecdotal reports suggest that its side effects are similar to those of THC. Common short-term side effects associated with THC, which might also be experienced with HHC, include:
- Dry Mouth
- Increased Heart Rate
- Low Blood Pressure
- Slower Reaction Times
- Tiredness
Does HHC show up in a drug test?
Although HHC is not the same as delta 8 or delta 9 THC, it can still potentially lead to a positive result on a drug test. This is because HHC has a similar chemical structure to these compounds and can metabolize in a similar way.
Most drug tests look for THC-COOH metabolites, which are produced when the body processes THC. Since HHC can produce similar metabolites, there is a chance that it could be detected in blood, urine, or saliva tests.
Where can I buy safe and potent HHC products?
XLR8 Delta is a reputable online store known for selling federally legal HHC products. They provide Certificates of Analysis (COAs) to prove the potency and purity of their products, ensuring quality and safety. XLR8 Delta offers affordable HHC products without compromising on quality, making them a trusted choice for consumers seeking reliable options.
References:
A Survey Study of Individuals Using Hexahydrocannabinol Cannabis Products: Use Patterns and Perceived Effects; Morgan L Ferretti, L Riley Gournay, Mia G Bingaman, Ellen W Leen-Feldner (https://pubmed.ncbi.nlm.nih.gov/37934167/)
Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis; Dinesh Thapa, Jong Suk Lee, Se-Woong Heo, Yong Rok Lee, Keon Wook Kang, Mi-Kyoung Kwak, Han Gon Choi, Jung-Ae Kim (https://pubmed.ncbi.nlm.nih.gov/20950604/)
Conversion of cannabidiol to Δ9-tetrahydrocannabinol and related cannabinoids in artificial gastric juice, and their pharmacological effects in mice; Kazuhito Watanabe, Yuka Itokawa, Satoshi Yamaori, Ikuo Yamamoto (https://www.researchgate.net/figure/Antinociceptive-effects-of-9a-OH-HHC-and-8-OH-iso-HHC-in-mice_tbl1_225788188)
